Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.40 |
| ▸ | PTGIR | P43119 | 3/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483275 | 0.85 | PTPN1 (0.41) | LTB4R2PTPN1 | |
| SCHEMBL8485734 | 0.79 | PTPN1 (0.43) | PTPN1 | |
| SCHEMBL8485704 | 0.78 | PTPN1 (0.42) | PTPN1DCLRE1B | |
| SCHEMBL8556010 | 0.73 | RXRA (0.49) | PTPN1 | |
| SCHEMBL3231875 | 0.71 | NPC1 (0.68) | PTPN1 | |
| SCHEMBL5696468 | 0.71 | LTB4R2 (0.48) | LTB4R2PTPN1 | |
| SCHEMBL2094984 | 0.70 | NPSR1 (0.48) | PTGIRPTGER4PTGER3PTGER2PTGDR | |
| SCHEMBL10399737 | 0.70 | NPC1 (0.71) | PTGIRPTGER4PTGER3PTGER2PTGDR | |
| SCHEMBL1561385 | 0.69 | ALDH1A1 (0.63) | — | |
| SCHEMBL2094982 | 0.69 | PTGIR (0.47) | PTGIRPTGER4PTGER3PTGER2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |