Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.40 |
| ▸ | HNF4A | P41235 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.38 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483275 | 0.87 | PTPN1 (0.41) | PTPN1ALDH1A1MAPTALOX15 | |
| SCHEMBL1239567 | 0.80 | PTPN1 (0.59) | PTPN1CDC25BATM | |
| SCHEMBL8479230 | 0.78 | LTB4R2 (0.42) | PTPN1DCLRE1B | |
| SCHEMBL8485734 | 0.78 | PTPN1 (0.43) | PTPN1ALDH1A1ALOX15 | |
| SCHEMBL17197587 | 0.76 | CDC25B (0.50) | PTPN1CDC25BATMHNF4AACMSD | |
| SCHEMBL3231875 | 0.75 | NPC1 (0.68) | PTPN1ATMALDH1A1MAPTALOX15 | |
| SCHEMBL5696468 | 0.75 | LTB4R2 (0.48) | PTPN1ALDH1A1MAPTALOX15 | |
| SCHEMBL8556010 | 0.75 | RXRA (0.49) | PTPN1 | |
| SCHEMBL4022644 | 0.74 | ALDH1A1 (0.48) | PTPN1CDC25BATMHNF4AACMSD | |
| SCHEMBL1561385 | 0.73 | ALDH1A1 (0.63) | ATMAOC3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |