Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947292 | 0.81 | HTT (0.46) | NPC1RAB9AL3MBTL1ALDH1A1HTT | |
| SCHEMBL8595337 | 0.80 | CYP11B2 (0.44) | CYP11B2NAMPTALDH1A1LMNATSHR | |
| SCHEMBL27527912 | 0.80 | L3MBTL1 (0.45) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8479405 | 0.79 | NPC1 (0.44) | NPC1RAB9AL3MBTL1LMNAHTT | |
| SCHEMBL8482634 | 0.79 | BACE1 (0.48) | CYP11B2NPC1RAB9AL3MBTL1HTT | |
| SCHEMBL8479651 | 0.75 | BACE1 (0.50) | CYP11B2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL8550527 | 0.74 | BACE1 (0.48) | CYP11B2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL8592667 | 0.72 | CLK4 (0.41) | NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL8479680 | 0.72 | CLK4 (0.41) | NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL5016747 | 0.72 | CHRNA7 (0.57) | L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |