SCHEMBL8480

SCHEMBL8480

O=[C]OCc1ccc(Br)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.52
APP P05067 1/20 0.42
RXRA P19793 1/20 0.42
RXRB P28702 1/20 0.42
MAOB P27338 6/20 0.41
KDM4E B2RXH2 2/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
KMT2A Q03164 1/20 0.41
MAOA P21397 3/20 0.40
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
HTR2A P28223 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3092949 0.79 IDO1 (0.50) IDO1APPKDM4ECA2KMT2A
SCHEMBL28428894 0.78 TAAR1 (0.45) IDO1MAOBKDM4EMAOAFFAR1
SCHEMBL6949336 0.77 RXRA (0.42) RXRARXRBCA2KMT2ATAAR1
SCHEMBL8816 0.77 IDO1 (0.52) IDO1APPMAOBCA1CA2
SCHEMBL513841 0.77 AGXT (0.52) IDO1MAOBCA1CA2CA9
SCHEMBL513966 0.77 CYP3A4 (0.52) IDO1APPRXRARXRB
SCHEMBL177563 0.77 ALDH1A1 (0.44) APPMAOBCA2CA9KMT2A
SCHEMBL95538 0.77 IDO1 (0.52) IDO1APPMAOBCA12CA1
SCHEMBL17803203 0.77 ABAT (0.46) MAOBCA12CA1CA2CA7
SCHEMBL29048052 0.77 IDO1 (0.52) IDO1APPRXRARXRBMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6828 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023151188-A1 GREEN SYNTHESIS METHOD OF ANTIVIRAL DRUG INTERMEDIATE 上海皓元医药股份有限公司 2023-08-17 WO claimed
CN-114671798-B Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-08-16 CN claimed
CN-114671798-A Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-06-28 CN claimed
EP-2788353-B1 CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS Clarity Pharmaceuticals Ltd (AU) 2022-05-18 EP claimed
EP-3053944-B1 METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END, POLYMERIZATION INITIATOR FOR USE IN THE SAME, AND ALCOHOL COMPOUND AS RAW MATERIAL FOR THE POLYMERIZATION INITIATOR SHINETSU CHEMICAL CO (JP) 2021-10-06 EP claimed
US-20210300932-A1 CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN ZEALAND PHARMA A/S (DK) 2021-09-30 US claimed
US-11072616-B2 Cyclic peptides targeting alpha-4-beta-7 integrin UNIVERSITE DE MONTREAL (CA) 2021-07-27 US claimed
EP-3280721-B1 PROCESS FOR PREPARATION OF NITROGEN MUSTARD DERIVATIVES ONCOPEPTIDES AB (SE) 2020-07-22 EP claimed
CN-108147972-B Preparation method of vipatavir intermediate and analogue thereof 成都西岭源药业有限公司 2020-07-10 CN claimed
US-9822146-B2 Process for the manufacture of degarelix and its intermediates FERRING B.V. (NL) 2017-11-21 US claimed
US-4223019-A Synthetic peptides having pituitary growth hormone releasing activity BECKMAN INSTRUMENTS, INC. (US) 1980-09-16 US claimed
US-4223020-A Synthetic peptides having pituitary growth hormone releasing activity BECKMAN INSTRUMENTS, INC. (US) 1980-09-16 US claimed
EP-0011283-A1 New lactyl tetrapeptide, processes for preparation thereof and pharmaceutical compositions containing it FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-05-28 EP claimed
US-3988308-A (Tyr3, Tyr14)-SRIF and intermediates AMERICAN HOME PRODUCTS CORPORATION (US) 1976-10-26 US claimed
US-3978063-A 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-08-31 US claimed
US-3971737-A [2-Methyl-Ala6 ]LRH AMERICAN HOME PRODUCTS CORPORATION (US) 1976-07-27 US claimed
US-3941763-A POLYPEPTIDE AMERICAN HOME PRODUCTS CORPORATION (US) 1976-03-02 US claimed
US-3940380-A P-Glu-D-Phe-Trp-Ser-Tyr-2-Me.Ala-Leu-Arg-Pro-NH2 and intermediates AMERICAN HOME PRODUCTS CORPORATION (US) 1976-02-24 US claimed
US-3937695-A P-Glu-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2 and intermediates AMERICAN HOME PRODUCTS CORPORATION (US) 1976-02-10 US claimed
US-3933782-A (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates AMERICAN HOME PRODUCTS CORPORATION (US) 1976-01-20 US claimed