SCHEMBL8480342

SCHEMBL8480342

Nc1ccc(NC(=O)c2ccc3cc(O)c(C(=O)Nc4ccccc4)cc3c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLAU P00749 4/20 0.62
PLG P00747 4/20 0.62
F2 P00734 2/20 0.62
PLAT P00750 2/20 0.62
F10 P00742 1/20 0.62
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
MEN1 O00255 4/20 0.56
KMT2A Q03164 4/20 0.56
KLK1 P06870 3/20 0.56
POLB P06746 3/20 0.56
KLKB1 P03952 1/20 0.56
PRSS1 P07477 1/20 0.56
KLK6 Q92876 2/20 0.56
DEGS1 O15121 1/20 0.56
SRC P12931 1/20 0.54
CASP3 P42574 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
GPR39 O43194 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7047835 0.93 PLAU (0.59) PLAUPLGF2PLATF10
SCHEMBL6575251 0.92 PLAU (0.64) PLAUPLGF2PLATF10
SCHEMBL8485202 0.91 PLG (0.58) PLAUPLGF2PLATF10
SCHEMBL8484998 0.90 SRC (0.58) PLAUPLGF2PLATF10
SCHEMBL13380512 0.87 KMT2A (0.73) PLAUPLGF2PLATF10
SCHEMBL30897005 0.87 KMT2A (0.73) PLAUPLGF2PLATF10
SCHEMBL8479137 0.86 PLG (0.62) PLAUPLGF2PLATF10
SCHEMBL8481738 0.86 PLG (0.62) PLAUPLGF2PLATF10
SCHEMBL3925183 0.85 PLG (0.62) PLAUPLGF2PLATF10
SCHEMBL3914853 0.85 PLAU (0.62) PLAUPLGF2PLATF10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6005085-A NOVEL CONDENSED AZO COMPOUNDS USING BISAMIDE COMPOUNDS OF 2-HYDROXYNAPHTHALENE-3,6-DICARBOXYLIC ACID, AMIDE, OR ESTER AS THE COUPLERS, WHICH HAVE EXCELLENT PROPERTIES SUCH AS EXCELLENT WATER RESISTANCE, CHEMICAL RESISTANCE, SOLVENT KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) 1999-12-21 US disclosed
EP-0913430-A1 CONDENSED AZO COMPOUND AND PROCESS FOR PRODUCING THE SAME KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) 1999-05-06 EP disclosed