Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.55 |
| ▸ | MMP9 | P14780 | 8/20 | 0.55 |
| ▸ | MMP8 | P22894 | 8/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.41 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484193 | 1.00 | MMP2 (0.55) | MMP2MMP9MMP8HRH4MMP1 | |
| SCHEMBL8484478 | 0.91 | MMP9 (0.47) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8485801 | 0.91 | CTSS (0.46) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8484484 | 0.91 | MMP9 (0.47) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8485799 | 0.91 | CTSS (0.46) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8481408 | 0.90 | HRH4 (0.56) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8481399 | 0.90 | HRH4 (0.56) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8481892 | 0.90 | HRH4 (0.56) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8486197 | 0.89 | HRH4 (0.45) | MMP2MMP9MMP8HRH4MME | |
| SCHEMBL8486193 | 0.89 | HRH4 (0.45) | MMP2MMP9MMP8HRH4MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | claimed |
| WO-1997026246-A1 | SUBSTITUTED HISTIDINE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | claimed |
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | disclosed |