Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847222 | 0.88 | DGAT1 (0.45) | FAAHSCN9ADGAT1SMN1; SMN2LMNA | |
| SCHEMBL846587 | 0.85 | FAAH (0.54) | FAAHDGAT1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL846441 | 0.84 | NPC1 (0.57) | SMN1; SMN2LMNAKDM4ENPC1HSD17B10 | |
| SCHEMBL846604 | 0.77 | KDR (0.58) | FAAHSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL4108874 | 0.74 | KDR (0.63) | SMN1; SMN2LMNAKDM4ENPC1HSD17B10 | |
| SCHEMBL846733 | 0.72 | TRPV1 (0.56) | DGAT1KDM4ENPC1RAB9ATRPV1 | |
| SCHEMBL28495228 | 0.69 | KDR (0.59) | SCN9ASMN1; SMN2LMNAKDM4ENPC1 | |
| SCHEMBL31178440 | 0.68 | FAAH (1.00) | FAAHSMN1; SMN2KDM4ENPC1HSD17B10 | |
| SCHEMBL860051 | 0.68 | KDM4E (0.49) | SCN9ASMN1; SMN2LMNAKDM4ENPC1 | |
| SCHEMBL29739663 | 0.68 | KCNH2 (0.51) | DGAT1SMN1; SMN2LMNACYP3A4SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |