Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL848254 | 0.88 | FAAH (0.52) | DGAT1TRPV1SCN9AHSD17B10RAB9A | |
| SCHEMBL846733 | 0.85 | TRPV1 (0.56) | DGAT1TRPV1RAB9AKDM4ENPC1 | |
| SCHEMBL846441 | 0.84 | NPC1 (0.57) | TRPV1HSD17B10RAB9ALMNAPOLB | |
| SCHEMBL846225 | 0.77 | TRPV1 (0.60) | TRPV1RAB9AKDM4ENPC1 | |
| SCHEMBL846587 | 0.72 | FAAH (0.54) | DGAT1TRPV1RAB9ALMNATSHR | |
| SCHEMBL4108874 | 0.72 | KDR (0.63) | TRPV1HSD17B10RAB9ALMNAPOLB | |
| SCHEMBL846566 | 0.71 | HSD17B10 (0.44) | TRPV1HSD17B10RAB9ALMNAPOLB | |
| SCHEMBL30588392 | 0.71 | DGAT1 (0.47) | DGAT1TRPV1CHRM4CYP3A4SOAT1 | |
| SCHEMBL846485 | 0.70 | HSD17B10 (0.43) | TRPV1HSD17B10RAB9ALMNAPOLB | |
| SCHEMBL30588459 | 0.70 | DGAT1 (0.52) | DGAT1TRPV1CYP3A4SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |