SCHEMBL8483151

SCHEMBL8483151

FC(F)(F)c1[nH]c(-c2ccc(Cl)c(Cl)c2)c(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AHR P35869 5/20 0.42
CYP1B1 Q16678 1/20 0.41
GYS1 P13807 1/20 0.39
IKBKB O14920 1/20 0.36
PSD A5PKW4 3/20 0.34
NOTUM Q6P988 3/20 0.34
MEN1 O00255 2/20 0.34
HTT P42858 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.34
USP2 O75604 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
PKM P14618 1/20 0.34
ALOX12 P18054 1/20 0.34
KIF20B Q96Q89 1/20 0.34
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
ARF6 P62330 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8799220 0.86 AHR (0.38) AHRCYP1B1GYS1IKBKBPSD
SCHEMBL9189622 0.82 IDO1 (0.39) AHRCYP1B1GYS1NOTUMMEN1
SCHEMBL9216333 0.81 KCNQ3 (0.35) GYS1PSDMEN1HTTKMT2A
SCHEMBL8976164 0.74 IDO1 (0.40) AHRCYP1B1GYS1NOTUMMEN1
SCHEMBL9336031 0.72 MAPK14 (0.39) AHRGYS1NOTUMMEN1HTT
SCHEMBL9015099 0.71 PSD (0.47) GYS1PSDMEN1HTTKMT2A
SCHEMBL9015125 0.71 PSD (0.47) GYS1PSDMEN1HTTKMT2A
SCHEMBL9446465 0.71 ALDH1A1 (0.45) GYS1PSDMEN1HTTKMT2A
SCHEMBL9339859 0.70 PSD (0.41) AHRGYS1PSDMEN1HTT
SCHEMBL9015089 0.70 AHR (0.44) AHRCYP1B1GYS1IKBKBNOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994389-A INSECTICIDE BAYER AKTIENGESELLSCHAFT (DE) 1999-11-30 US disclosed
US-5726199-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1998-03-10 US disclosed
EP-0751935-A1 N-ARYL AND N-ALKYLSULPHONYLAMINALS AS PESTICIDES BAYER AG (DE) 1997-01-08 EP disclosed
WO-1995025719-A1 N-ARYL AND N-ALKYLSULPHONYLAMINALS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1995-09-28 WO disclosed