Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491844 | 0.83 | KDM4E (0.48) | HPGDALDH1A1KDM4ESMN1; SMN2PARP1 | |
| SCHEMBL8478795 | 0.82 | HPGD (0.44) | HPGDALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL7484251 | 0.80 | HPGD (0.45) | HPGDALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL7486485 | 0.78 | HPGD (0.43) | HPGDKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL6402848 | 0.77 | HPGD (0.57) | HPGDALDH1A1NQO2KDM4EMAPT | |
| SCHEMBL30273080 | 0.72 | HPGD (0.60) | HPGDALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6783276 | 0.72 | HPGD (0.60) | HPGDALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL25187778 | 0.70 | KDM4E (0.38) | HPGDALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL25607486 | 0.69 | PARP1 (0.35) | HPGDALDH1A1NQO2KDM4EHTT | |
| SCHEMBL6576708 | 0.69 | ALDH1A1 (0.56) | HPGDALDH1A1NQO2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914402-A | Process for preparing 1-aryl-4-oxopyrrolo 3,2-c! quinoline derivatives | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-06-22 | — | — | US | disclosed |
| EP-0853622-A1 | PROCESS FOR PREPARING 1-ARYL-4-OXOPYRROLO 3,2-c]QUINOLINE DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997044342-A1 | PROCESS FOR PREPARING 1-ARYL-4-OXOPYRROLO[3,2-c]QUINOLINE DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1997-11-27 | — | — | WO | disclosed |
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | disclosed |
| US-5051508-A | Antisecretory agents and enzyme inhibitors as antiulcer agents | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1991-09-24 | — | — | US | disclosed |
| EP-0307078-A1 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1989-03-15 | — | — | EP | disclosed |