Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12188926 | 0.82 | HPGD (0.47) | APLNRGRIA2ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL10192138 | 0.82 | ALDH1A1 (0.49) | APLNRGRIA2ALDH1A1POLBLMNA | |
| SCHEMBL4351827 | 0.80 | MAPT (0.43) | APLNRGRIA2ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL14297420 | 0.80 | TSHR (0.50) | APLNRGRIA2ALDH1A1KDM4EMMP3 | |
| SCHEMBL7230524 | 0.80 | CA1 (0.44) | APLNRGRIA2ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL19563399 | 0.80 | PYCR1 (0.46) | APLNRGRIA2ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL2057187 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL14132725 | 0.77 | PYCR1 (0.49) | APLNRGRIA2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12169353 | 0.77 | KCNH2 (0.43) | GRIA2ALDH1A1LMNANR1H3 | |
| SCHEMBL11609 | 0.77 | APLNR (0.71) | APLNRALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916891-A | CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |
| US-5656644-A | CYTOKINE SUPPRESSORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |