Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 10/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480626 | 0.88 | XDH (0.48) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8482019 | 0.88 | GAA (0.51) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8484222 | 0.88 | RAB9A (0.49) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8484216 | 0.88 | RAB9A (0.49) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8485017 | 0.85 | MAPT (0.49) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8484282 | 0.85 | XDH (0.51) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8484617 | 0.84 | XDH (0.52) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8480366 | 0.79 | XDH (0.54) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8480356 | 0.79 | XDH (0.54) | NPC1RAB9AKMT2AXDHMAPT | |
| SCHEMBL8481591 | 0.78 | NPC1 (0.55) | NPC1RAB9AKMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990118-A | NOVEL PURINE COMPOUNDS AND TRIAZOLOPURINE COMPOUNDS WHICH INHIBIT XANTHINE OXIDASE; REMEDIES FOR HYPERURICEMIA, AND AS PREVENTIVE AND THERAPEUTIC AGENTS FOR GOUT | YAMASA CORPORATION (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0811624-A1 | PURINE COMPOUNDS AND XANTHINE OXIDASE INHIBITORS | YAMASA CORPORATION (JP) | 1997-12-10 | — | — | EP | disclosed |