Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486679 | 0.91 | ADAM17 (0.41) | MEN1KMT2AADAM17LMNAL3MBTL1 | |
| SCHEMBL8486415 | 0.91 | LMNA (0.40) | MEN1KMT2AADAM17LMNAL3MBTL1 | |
| SCHEMBL8485582 | 0.80 | FFAR1 (0.40) | MMP1MMP2MMP9MMP13MEN1 | |
| SCHEMBL8486657 | 0.79 | GRIN2B (0.45) | KMT2AGRIN2B | |
| Hydrochloric Acid SCHEMBL8483457 | 0.78 | GRIN2B (0.45) | MEN1ALDH1A1KMT2AGRIN2B | |
| Fumaric Acid SCHEMBL8482195 | 0.75 | GRIN2B (0.40) | LMNAPPARGPPARAGRIN2B | |
| SCHEMBL8486681 | 0.72 | APP (0.43) | MEN1KMT2AADAM17FFAR1GRIN2B | |
| SCHEMBL8486420 | 0.72 | MAPT (0.44) | MEN1ALDH1A1KMT2AADAM17LMNA | |
| SCHEMBL8486964 | 0.70 | NPC1 (0.42) | YAP1MMP1MEN1ALDH1A1RECQL | |
| SCHEMBL8486371 | 0.70 | LMNA (0.39) | YAP1MMP1MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889026-A | 4-hydroxy-piperodine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-03-30 | — | — | US | disclosed |