Known targets — ChEMBL curated mechanism
FLT3KDRKITPDGFRAPDGFRBPRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3
The experimentally established mechanism targets of Midostaurin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ known ✓ | Q04759 | 19/20 | 1.00 |
| ▸ | PRKD3 known ✓ | O94806 | 17/20 | 1.00 |
| ▸ | PRKCG known ✓ | P05129 | 17/20 | 1.00 |
| ▸ | PRKCB known ✓ | P05771 | 17/20 | 1.00 |
| ▸ | PRKCA known ✓ | P17252 | 17/20 | 1.00 |
| ▸ | PRKCH known ✓ | P24723 | 17/20 | 1.00 |
| ▸ | PRKCI known ✓ | P41743 | 17/20 | 1.00 |
| ▸ | PRKCE known ✓ | Q02156 | 17/20 | 1.00 |
| ▸ | PRKCZ known ✓ | Q05513 | 17/20 | 1.00 |
| ▸ | PRKCD known ✓ | Q05655 | 17/20 | 1.00 |
| ▸ | PRKD1 known ✓ | Q15139 | 17/20 | 1.00 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 1.00 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 1.00 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 1.00 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 1.00 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 1.00 |
| ▸ | PRKACA | P17612 | 17/20 | 1.00 |
| ▸ | PRKACB | P22694 | 17/20 | 1.00 |
| ▸ | PRKACG | P22612 | 16/20 | 1.00 |
| ▸ | EGFR | P00533 | 15/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midostaurin SCHEMBL29388922 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL8209330 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL13882519 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL29350876 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL14342262 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL20130811 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL13170170 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL8295379 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL22599853 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA | |
| Midostaurin SCHEMBL12941020 | 1.00 | PRKCQ (1.00) | PRKCQPRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230332104-A1 | ZBTB32 INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2023-10-19 | — | — | US | disclosed |
| EP-1812448-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230332104-A1 | ZBTB32 INHIBITORS AND USES THEREOF | IKZF2, IKZF3, BAZ2B | PRKCQ 1057/4885PRKD3 962/4885PRKCG 822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.