Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22589573 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19MGLL | |
| SCHEMBL7819807 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19MGLL | |
| SCHEMBL9236140 | 0.85 | BCHE (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19MGLL | |
| SCHEMBL8484189 | 0.84 | FAAH (0.62) | NPC1RAB9AMGLLFAAHCYP1A2 | |
| SCHEMBL21227845 | 0.83 | SIGMAR1 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19MGLL | |
| SCHEMBL30415448 | 0.82 | MAPT (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19BCHE | |
| SCHEMBL2830265 | 0.82 | CYP1A2 (0.52) | CYP2C19MGLLCYP1A2CYP2D6POLB | |
| SCHEMBL3554740 | 0.81 | SIGMAR1 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL13241619 | 0.81 | HTR2A (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19MGLL | |
| SCHEMBL15747761 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952354-A | ENZYME INHIBITORS OF CHLOESTEROL ESTER HYDROLASE AND/OR ACYL COENZYME A:CHLOESTEROL ACYLTRANSFERASE; INHIBIT THE ESTERIFICATION OF CHLOESTEROL AND REDUCE ABSORPTION THROUGH THE INTESTINE; CARBAMATES OF 4-8 MEMBERED AZACYCLOALKANOLS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0635501-A1 | Tris carbamic acid esters: inhibitors of cholesterol absorption; inhibitors of ACAT and CEH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-25 | — | — | EP | disclosed |