Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.62 |
| ▸ | MGLL | Q99685 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830265 | 0.85 | CYP1A2 (0.52) | MGLLCYP1A2CYP2D6 | |
| SCHEMBL8486237 | 0.84 | SMN1; SMN2 (0.52) | FAAHMGLLNPC1RAB9ACYP1A2 | |
| SCHEMBL8776624 | 0.84 | CYP1A2 (0.61) | FAAHMGLLCYP1A2CYP2D6 | |
| SCHEMBL9236525 | 0.82 | MGLL (0.51) | FAAHMGLLNPC1RAB9ACYP1A2 | |
| SCHEMBL8952503 | 0.82 | MGLL (0.48) | FAAHMGLLNPC1RAB9ACYP1A2 | |
| SCHEMBL9235325 | 0.82 | MGLL (0.51) | FAAHMGLLNPC1RAB9ACYP1A2 | |
| SCHEMBL2803619 | 0.81 | ALDH1A1 (0.58) | FAAHMGLLCYP1A2CYP2D6 | |
| SCHEMBL8750701 | 0.81 | MGLL (0.45) | FAAHMGLLNPC1RAB9ACYP1A2 | |
| SCHEMBL20625250 | 0.79 | GAA (0.51) | MGLLCYP1A2CYP2D6 | |
| SCHEMBL10195613 | 0.79 | CYP1A2 (0.63) | FAAHMGLLCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952354-A | ENZYME INHIBITORS OF CHLOESTEROL ESTER HYDROLASE AND/OR ACYL COENZYME A:CHLOESTEROL ACYLTRANSFERASE; INHIBIT THE ESTERIFICATION OF CHLOESTEROL AND REDUCE ABSORPTION THROUGH THE INTESTINE; CARBAMATES OF 4-8 MEMBERED AZACYCLOALKANOLS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0635501-A1 | Tris carbamic acid esters: inhibitors of cholesterol absorption; inhibitors of ACAT and CEH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-25 | — | — | EP | disclosed |