Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489385 | 0.91 | EGFR (0.57) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL7242679 | 0.86 | EGFR (0.74) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL8155324 | 0.84 | EGFR (0.55) | EGFRRIPK2EPHB2ERBB2ERBB4 | |
| SCHEMBL8155329 | 0.83 | EGFR (0.55) | EGFRRIPK2EPHB2ERBB2ERBB4 | |
| SCHEMBL8490274 | 0.82 | EGFR (0.54) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL8149145 | 0.79 | EGFR (0.66) | EGFRRIPK2EPHB2ERBB2ERBB4 | |
| SCHEMBL8150558 | 0.79 | EGFR (0.76) | EGFRRIPK2EPHB2ERBB2ERBB4 | |
| SCHEMBL8142454 | 0.78 | EGFR (0.55) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL7243958 | 0.78 | EGFR (0.71) | EGFRERBB2ERBB4KDR | |
| SCHEMBL8488612 | 0.78 | EGFR (0.51) | EGFRKDRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |