Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483161 | 0.70 | ADORA2A (0.32) | HPGDHSD17B10 | |
| SCHEMBL21617404 | 0.69 | POLB (0.47) | KDM4EHPGDTSHRHSD17B10POLB | |
| 1-Methylxanthine SCHEMBL12037451 | 0.66 | ADORA2A (0.54) | KDM4EHPGDTSHR | |
| SCHEMBL8481263 | 0.65 | HRH4 (0.33) | KDM4EHPGDHSD17B10POLBGRIN2D | |
| SCHEMBL8481258 | 0.65 | ADORA2A (0.39) | — | |
| SCHEMBL8485656 | 0.64 | ADORA2B (0.34) | — | |
| SCHEMBL8485775 | 0.63 | NPC1 (0.43) | KDM4EHPGDHSD17B10POLB | |
| SCHEMBL9240979 | 0.62 | ADORA2A (0.58) | HPGDHSD17B10 | |
| SCHEMBL13663975 | 0.60 | LMNA (0.33) | KDM4EHPGDPOLB | |
| SCHEMBL16852360 | 0.59 | JAK1 (0.44) | KDM4EHPGDTSHRHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990118-A | NOVEL PURINE COMPOUNDS AND TRIAZOLOPURINE COMPOUNDS WHICH INHIBIT XANTHINE OXIDASE; REMEDIES FOR HYPERURICEMIA, AND AS PREVENTIVE AND THERAPEUTIC AGENTS FOR GOUT | YAMASA CORPORATION (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0811624-A1 | PURINE COMPOUNDS AND XANTHINE OXIDASE INHIBITORS | YAMASA CORPORATION (JP) | 1997-12-10 | — | — | EP | disclosed |