Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL347426 | 0.89 | USP2 (0.43) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Glycerin SCHEMBL8486329 | 0.88 | LMNA (0.43) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Stearic Acid SCHEMBL11350239 | 0.88 | FFAR4 (0.56) | FFAR1FFAR4GPR84TSHRALDH1A1 | |
| Adipic Acid SCHEMBL4323531 | 0.87 | GPR84 (0.59) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Adipic Acid SCHEMBL207584 | 0.87 | GPR84 (0.59) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Adipic Acid SCHEMBL29226063 | 0.86 | GPR84 (0.45) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Adipic Acid SCHEMBL28497473 | 0.85 | GPR84 (0.56) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Tetraethylene Glycol SCHEMBL11643281 | 0.85 | GPR84 (0.56) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Di(Hydroxyethyl)Ether SCHEMBL28736949 | 0.85 | GPR84 (0.64) | FFAR1FFAR4GPR84CAMK2ALMNA | |
| Adipic Acid SCHEMBL2922617 | 0.85 | GPR84 (0.56) | FFAR1FFAR4GPR84CAMK2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101600747-B | Silylated polyurethane compositions and adhesives therefrom | MOMENTIVE PERFORMANCE MAT INC | 2013-10-30 | — | — | CN | disclosed |
| CN-101600747-A | The polyurethane composition of silanization and tackiness agent therefrom | MOMENTIVE PERFORMANCE MAT INC (US) | 2009-12-09 | — | — | CN | disclosed |
| US-5874576-A | 4,4'-(6-(BIS(DIALKYL)AMINO)-S-TRIAZIN-2,4-DIYL)RESORCINAL; SUNSCREEN AGENTS; PHOTOSTABILITY; COSMETICS; UV A RADIATION | GIVAUDAN-ROURE (INTERNATIONAL) SA (CH) | 1999-02-23 | — | — | US | disclosed |
| US-4812368-A | IMPREGNATING FOAM WITH POLYISOCYANATES | BASF AKTIENGESELLSCHAFT (DE) | 1989-03-14 | — | — | US | disclosed |
| US-4508774-A | Cellular, molded polyurethane parts, process for their preparation by thermoforming of polyester-urethane foam and their use | BASF AKTIENGESELLSCHAFT (DE) | 1985-04-02 | — | — | US | disclosed |
| US-4287307-A | MICROCELLULAR, PLASTICIZING, FOOTWEAR | PLASTICS TECHNOLOGY ASSOCIATES, INC. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4138356-A | Encapsulated flame retardant system | CHAMPION INTERNATIONAL CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |
| US-3968060-A | Encapsulated flame retardant system | CHAMPION INTERNATIONAL CORPORATION (US) | 1976-07-06 | — | — | US | disclosed |