Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22699771 | 0.71 | TKT (0.33) | — | |
| SCHEMBL30073942 | 0.71 | ITGB3 (0.54) | NPSR1ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL23455586 | 0.71 | ITGB3 (0.54) | NPSR1ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL21348071 | 0.71 | — | — | |
| SCHEMBL23341589 | 0.70 | KCNH2 (0.43) | HSD17B10ALDH1A1TP53TLR7 | |
| SCHEMBL6783633 | 0.68 | KEAP1 (0.52) | FFAR1NPSR1L3MBTL1KEAP1HDAC6 | |
| SCHEMBL3953029 | 0.67 | NPSR1 (0.40) | FFAR1NPSR1HSD17B10L3MBTL1POLB | |
| SCHEMBL7611074 | 0.66 | NPSR1 (0.52) | FFAR1NPSR1HSD17B10L3MBTL1POLB | |
| SCHEMBL22733678 | 0.66 | CYP2C19 (0.50) | FFAR1NPSR1POLBKEAP1FFAR4 | |
| SCHEMBL24248047 | 0.66 | FFAR1 (0.53) | FFAR1L3MBTL1POLBKEAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506779-B1 | (3-(4-(Pyridin-2-ylamino)-butyryl)-2,3,4,4a,9,9a-hexahydro-1H-3-aza-fluoren-9-yl)-acetic acid derivatives and related tricyclic indanyls as alphaVbeta3 and alphaVbeta5 integrin inhibitors for the treatment of cancer and unstable angina | JANSSEN PHARMACEUTICA NV (BE) | 2006-07-12 | — | — | EP | disclosed |