Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10710439 | 0.95 | KMT2A (0.46) | KMT2APTGS2PTGS1FGFR1SRC | |
| SCHEMBL30677890 | 0.87 | ABL1 (0.44) | KMT2APTGS2PTGS1ALDH1A1THRB | |
| SCHEMBL28518787 | 0.84 | PTGS1 (0.46) | KMT2APTGS2PTGS1FGFR1SRC | |
| SCHEMBL8479916 | 0.82 | PTGS2 (0.58) | KMT2APTGS2PTGS1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL6981180 | 0.80 | PTGS1 (0.43) | KMT2APTGS2PTGS1FGFR1SRC | |
| SCHEMBL2392888 | 0.79 | LMNA (0.46) | KMT2ACYP2C9CYP2C19ALDH1A1PPARA | |
| SCHEMBL1901275 | 0.78 | KMT2A (0.46) | KMT2AFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL10914468 | 0.78 | PPARA (0.42) | KMT2APTGS2ALDH1A1PPARAPPARG | |
| SCHEMBL4827831 | 0.77 | PTGS2 (0.67) | KMT2APTGS2PTGS1CYP2C9CYP2C19 | |
| SCHEMBL2393839 | 0.77 | PTGS2 (0.56) | KMT2APTGS2PTGS1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990158-A | EXTRACELLULAR MATRIX METALLOPROTEINASES INHIBITORS; ORAL ADMINISTRATION; BIOAVAILABILITY; E.G.,N-(2-(2'-(5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYLENE-OXY-2'-OXO-ETHYL)-5 -(4-METH-OXYPHENYL)OXY)PENTANOYL)PHENYLALANINE N-METHYLAMIDE | KOTOBUKI SEIYAKU CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |