Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484799 | 0.99 | LTB4R2 (0.34) | LTB4R2S1PR1PKMMEN1KMT2A | |
| SCHEMBL8811173 | 0.89 | S1PR1 (0.34) | LTB4R2S1PR1PKMMAOBACHE | |
| SCHEMBL8808994 | 0.88 | S1PR1 (0.34) | LTB4R2S1PR1PKMMAOBACHE | |
| SCHEMBL8484079 | 0.86 | LTB4R2 (0.40) | LTB4R2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL8487085 | 0.84 | LTB4R2 (0.36) | LTB4R2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1911 | 0.84 | LTB4R2 (0.48) | LTB4R2ACHEOXTRAVPR1A | |
| SCHEMBL8911282 | 0.83 | LTB4R2 (0.34) | LTB4R2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL8487872 | 0.83 | AGTR1 (0.34) | LTB4R2S1PR1PKMMEN1KMT2A | |
| SCHEMBL2366 | 0.83 | LTB4R2 (0.47) | LTB4R2ACHEOXTRAVPR1A | |
| SCHEMBL8483906 | 0.83 | AGTR1 (0.34) | LTB4R2S1PR1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |