Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581543 | 0.96 | DRD2 (0.69) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| Bromide SCHEMBL8484082 | 0.95 | DRD2 (0.68) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| SCHEMBL8485478 | 0.93 | DRD3 (0.58) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| SCHEMBL8482786 | 0.88 | DRD2 (0.67) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| Bromide SCHEMBL8483635 | 0.87 | DRD2 (0.66) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| Bromide SCHEMBL8485565 | 0.86 | DRD3 (0.62) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| SCHEMBL8486169 | 0.82 | DRD2 (0.68) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| SCHEMBL8484819 | 0.82 | DRD2 (0.94) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| Bromide SCHEMBL8583138 | 0.81 | DRD2 (0.67) | DRD3DRD2ADRA1AHRH4KCNH2 | |
| SCHEMBL8912854 | 0.79 | HTR1A (0.48) | DRD3DRD2ADRA1APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999021848-A2 | NOVEL 1-(N'-(ARYLALKYLAMINOALKYL))AMINOISOINDOLES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-05-06 | — | — | WO | claimed |