Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485571 | 0.93 | DRD2 (0.49) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL8690409 | 0.85 | HTR7 (0.52) | HTR1ADRD2HTR2ADRD3HTR7 | |
| Bromide SCHEMBL8486561 | 0.84 | HTR7 (0.51) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL8716529 | 0.79 | SLC6A4 (0.51) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL8488127 | 0.79 | DRD3 (0.64) | HTR1ADRD2HTR2ADRD3PDE4B | |
| SCHEMBL8486784 | 0.78 | HTR1A (0.61) | HTR1ADRD2HTR2ADRD3LMNA | |
| SCHEMBL8581543 | 0.76 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3DRD4 | |
| Bromide SCHEMBL8484082 | 0.75 | DRD2 (0.68) | HTR1ADRD2HTR2ADRD3DRD4 | |
| Bromide SCHEMBL7210662 | 0.74 | HTR1A (0.64) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL7207251 | 0.73 | KDM4E (0.51) | HTR1ADRD2HTR2ADRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656632-A | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 1997-08-12 | — | — | US | claimed |