Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488186 | 0.89 | GRIN1 (0.39) | GRIN1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8488905 | 0.88 | ALDH1A1 (0.38) | GRIN1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8485125 | 0.86 | ALDH1A1 (0.48) | GRIN1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8488434 | 0.86 | GRIN1 (0.43) | GRIN1ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL8488354 | 0.86 | GRIN1 (0.40) | GRIN1ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL8930635 | 0.81 | GRIN1 (0.36) | GRIN1MEN1KMT2A | |
| SCHEMBL8488510 | 0.79 | GRIN1 (0.49) | GRIN1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8650855 | 0.78 | GRIN1 (0.42) | GRIN1RAB9AMEN1KMT2APKM | |
| SCHEMBL8487378 | 0.78 | UTS2R (0.34) | MEN1KMT2A | |
| SCHEMBL8487638 | 0.77 | GRIN1 (0.37) | GRIN1ALDH1A1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863917-A | ANXIOLYTIC AGENT, ANTICONVULSANTS, ANALGESICS AND NEUROPROTECTIVES. | PFIZER, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997031902-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-04 | — | — | WO | disclosed |
| EP-0792874-A1 | Quinoxaline derivatives useful in therapy | Pfizer Limited (GB) | 1997-09-03 | — | — | EP | disclosed |