Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398649 | 0.91 | ITGB3 (0.43) | PLATCTSSPKMPLAUF10 | |
| SCHEMBL7408339 | 0.89 | PLAT (0.42) | PLATCTSSPKMPLAUF10 | |
| SCHEMBL1387237 | 0.86 | F2 (0.43) | PLAUF10F2ITGB3ITGA2B | |
| SCHEMBL1387213 | 0.86 | PLAT (0.42) | PLATCTSSPKMPLAUF10 | |
| SCHEMBL7402857 | 0.85 | F10 (0.43) | PKMPLAUF10F2ITGB3 | |
| SCHEMBL7403220 | 0.84 | PKM (0.51) | CTSSPKMF10IDO1KAT6A | |
| SCHEMBL7395471 | 0.82 | F2 (0.43) | PLAUF10F2ITGB3ITGA2B | |
| SCHEMBL1387418 | 0.81 | ITGB3 (0.43) | PLATPLAUF10F2ITGB3 | |
| SCHEMBL7408433 | 0.81 | PLAT (0.41) | PLATCTSSPKMPLAUF10 | |
| SCHEMBL7397980 | 0.78 | F2 (0.50) | PLAUF10F2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965559-A | STRONG INHIBITORY EFFECT AGAINST THE ACTIVATED COAGULATION PROTEASE KNOWN AS FACTOR XA; PREVENTION OF THE CLEAVAGE OF PROTHROMBIN TO THROMBIN; AMINO-SUBSTITUTED PYRIMIDINES AMIDINE GROUP-FREE | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |