SCHEMBL8489161

SCHEMBL8489161

CC(=O)NC[C@H]1CN(c2ccc(-c3ccncc3)cc2)C(=O)O1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.55
MAOB P27338 2/20 0.55
CALML3 P27482 2/20 0.55
LMNA P02545 1/20 0.55
PTGS1 P23219 1/20 0.55
SDHA P31040 1/20 0.55
F10 P00742 7/20 0.53
ABCB11 O95342 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8489164 1.00 MAOA (0.55) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL13298924 0.93 MAOA (0.61) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL8311890 0.90 MAOA (0.59) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL9550276 0.88 MAOA (0.57) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL9550299 0.88 MAOA (0.57) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL9550262 0.88 MAOA (0.57) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL10423881 0.88 ABCB11 (0.51) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL21324902 0.88 ABCB11 (0.51) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL10425344 0.87 MAOA (0.54) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL9550268 0.87 ABCB11 (0.56) MAOAMAOBCALML3LMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof ARRAKIS THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof ARRAKIS THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2023-10-05 US disclosed
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2023-10-05 US disclosed
US-20190270723-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2019-09-05 US disclosed
WO-1999033839-A1 CEPHEM DERIVATIVES AND A METHOD FOR PRODUCING THE COMPOUNDS AND AN ANTIBACTERIAL COMPOSITION CONTAINING THE COMPOUNDS CHEIL JEDANG CORPORATION (KR) 1999-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190270723-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF NSUN3, NSUN2, TARBP1 MAOA 2886/4885MAOB 1343/4885CALML3 2458/4885
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF NSUN3, NSUN2, TARBP1 MAOA 2886/4885MAOB 1343/4885CALML3 2458/4885
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof NSUN3, NSUN2, TARBP1 MAOA 2886/4885MAOB 1343/4885CALML3 2458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.