Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15268906 | 0.84 | DGAT1 (0.36) | DGAT1CTSKCTSSALDH1A1TSHR | |
| SCHEMBL14556812 | 0.79 | DGAT1 (0.39) | DGAT1CTSKCTSSALDH1A1TSHR | |
| SCHEMBL3542102 | 0.78 | ALDH1A1 (0.38) | DGAT1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8263519 | 0.77 | DGAT1 (0.42) | DGAT1CTSKCTSSTSHRCTSL | |
| SCHEMBL1963 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL13992304 | 0.73 | DGAT1 (0.34) | DGAT1CTSKCTSS | |
| SCHEMBL9755814 | 0.73 | DGAT1 (0.44) | DGAT1CTSKCTSSCTSLCTSB | |
| SCHEMBL17617175 | 0.72 | DGAT1 (0.36) | DGAT1CTSKCTSSMEN1KMT2A | |
| SCHEMBL17617225 | 0.72 | DGAT1 (0.36) | DGAT1CTSKCTSSMEN1KMT2A | |
| SCHEMBL31131830 | 0.70 | PTPRB (0.42) | CTSKCTSSALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |