Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 15/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998234 | 0.74 | GRM1 (1.00) | GRM1EGFRERBB2ERBB4KMT2A | |
| SCHEMBL8307733 | 0.73 | KMT2A (0.64) | KMT2A | |
| SCHEMBL8490286 | 0.72 | KMT2A (0.40) | EGFRKMT2A | |
| SCHEMBL29714896 | 0.72 | GRM1 (0.70) | GRM1EGFRERBB2KMT2AMEN1 | |
| SCHEMBL22604134 | 0.72 | GRM1 (0.70) | GRM1EGFRERBB2KMT2AMEN1 | |
| SCHEMBL8783016 | 0.72 | GRM4 (0.49) | EGFRERBB2 | |
| SCHEMBL8305842 | 0.70 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL8082013 | 0.70 | EGFR (0.74) | GRM1EGFRERBB2 | |
| SCHEMBL13402698 | 0.69 | EGFR (0.62) | EGFR | |
| SCHEMBL13402694 | 0.69 | EGFR (0.62) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |