Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 3/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998232 | 0.80 | EGFR (0.46) | KMT2AAURKARPS6KB1CSF1REGFR | |
| SCHEMBL8082010 | 0.77 | SYK (0.46) | EGFRKDRSYKCSNK2A1 | |
| SCHEMBL8150757 | 0.75 | PDE7A (0.38) | GRM4AURKARPS6KB1EGFRPIM1 | |
| SCHEMBL8487402 | 0.73 | EGFR (0.30) | EGFRPIM1PIM2KDRCSNK2A2 | |
| SCHEMBL8490290 | 0.72 | GRM1 (0.58) | KMT2AEGFR | |
| SCHEMBL2986229 | 0.72 | AURKA (0.45) | AURKARPS6KB1EGFRKDRSYK | |
| SCHEMBL8307733 | 0.68 | KMT2A (0.64) | KMT2ABRAFHDAC1F2RL1 | |
| SCHEMBL8096003 | 0.67 | KDM4C (0.38) | KMT2AHDAC1EGFRSYK | |
| SCHEMBL2989950 | 0.67 | EGFR (0.47) | AURKARPS6KB1CSF1REGFRKDR | |
| SCHEMBL8093494 | 0.66 | XDH (0.33) | KMT2ACSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |