Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306657 | 0.78 | KMT2A (0.58) | KMT2ANPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7090488 | 0.77 | JAK2 (0.53) | KMT2AJAK2TYK2SMN1; SMN2CHRM2 | |
| SCHEMBL9187082 | 0.76 | KMT2A (0.59) | KMT2ANPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7571479 | 0.74 | JAK2 (0.44) | KMT2AJAK2TYK2NPC1RAB9A | |
| 4-Aminophenol SCHEMBL2099615 | 0.73 | NPC1 (0.50) | KMT2ANPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7080355 | 0.73 | MAPT (0.47) | KMT2AJAK2TYK2NPC1RAB9A | |
| SCHEMBL27805818 | 0.72 | KMT2A (0.77) | KMT2ANPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL8309451 | 0.72 | JAK2 (0.61) | KMT2AJAK2TYK2NPC1RAB9A | |
| SCHEMBL8305769 | 0.72 | RAB9A (0.49) | KMT2AJAK2TYK2NPC1RAB9A | |
| SCHEMBL1324 | 0.71 | NPC1 (0.62) | KMT2ANPC1RAB9AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |