SCHEMBL8490674

SCHEMBL8490674

CCOC(=O)c1ccc(SC)cc1[N+](=O)[O-]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.50
SMN1; SMN2 Q16637 4/20 0.50
LMNA P02545 4/20 0.50
POLB P06746 3/20 0.50
NPSR1 Q6W5P4 2/20 0.50
GALR2 O43603 1/20 0.50
MITF O75030 1/20 0.50
HSP90AA1 P07900 1/20 0.50
HPGD P15428 1/20 0.50
XBP1 P17861 1/20 0.50
CCR6 P51684 1/20 0.50
KMT2A Q03164 2/20 0.45
CACNA1C Q13936 2/20 0.45
GSTP1 P09211 1/20 0.45
GSTM2 P28161 1/20 0.45
MAPT P10636 4/20 0.44
RAB9A P51151 2/20 0.44
NPC1 O15118 2/20 0.44
PKM P14618 1/20 0.44
CRHBP P24387 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6493349 0.84 SIRT6 (0.44) ALDH1A1SMN1; SMN2POLBHPGDKMT2A
SCHEMBL16529634 0.82 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL2126420 0.81 CA12 (0.62) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL6750268 0.81 SMN1; SMN2 (0.65) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL6422578 0.81 KMT2A (0.65) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL11724076 0.81 TSHR (0.56) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL31391703 0.80 MAPT (0.55) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL28999592 0.80 SMN1; SMN2 (0.53) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL6350616 0.80 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1
SCHEMBL3092769 0.80 MAPT (0.55) ALDH1A1SMN1; SMN2LMNAPOLBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116947715-A Preparation method of mesotrione intermediate 帕潘纳(北京)科技有限公司 2023-10-27 CN disclosed
US-5859283-A TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE RHONE-POULENC AGRICULTURE LIMITED (GB) 1999-01-12 US disclosed
US-5747424-A HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-05-05 US disclosed
US-5656573-A Herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-12 US disclosed
US-5650533-A Intermediates to herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-07-22 US disclosed
CN-1020603-C METHOD FOR PREPARATION OF MERCAPTOBENZOATES ICI AMERICA INC (US) 1993-05-12 CN disclosed
CN-87107367-A Preparation method of mercaptobenzoate 1988-12-28 CN disclosed