Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491267 | 0.85 | ALDH1A1 (0.42) | MAPTPOLBPKMALDH1A1L3MBTL1 | |
| SCHEMBL12802351 | 0.80 | ALDH1A1 (0.55) | MAPTPKMALDH1A1L3MBTL1 | |
| SCHEMBL12556696 | 0.80 | LMNA (0.53) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL5830639 | 0.78 | ESR1 (0.46) | ALDH1A1L3MBTL1ELANEESR1 | |
| SCHEMBL5733364 | 0.77 | LMNA (0.50) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL6428739 | 0.77 | LMNA (0.50) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL5830105 | 0.76 | ESR1 (0.55) | ALDH1A1ESR1 | |
| SCHEMBL5830171 | 0.76 | ESR1 (0.43) | ALDH1A1L3MBTL1ELANEESR1 | |
| SCHEMBL14763892 | 0.75 | NPC1 (0.47) | MAPTPOLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL6554130 | 0.75 | POLB (0.66) | MAPTPOLBPKMLMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999029673-A1 | SELECTIVE β3 ADRENERGIC AGONISTS | ELI LILLY AND COMPANY (US) | 1999-06-17 | — | — | WO | disclosed |
| WO-1998009625-A1 | SELECTIVE β3 ADRENERGIC AGONISTS | ELI LILLY AND COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |