Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491737 | 0.82 | CHRNB2 (0.46) | IDO1LRRK2CYP11B2PIM1ALPL | |
| SCHEMBL8490727 | 0.79 | AXL (0.51) | AXLADORA2AIDO1LRRK2MAP2K4 | |
| SCHEMBL14809869 | 0.75 | ADORA2A (0.58) | AXLADORA2AADORA1IDO1LRRK2 | |
| SCHEMBL1250789 | 0.70 | CYP11B2 (0.47) | ADORA2AADORA1IDO1LRRK2CYP11B2 | |
| SCHEMBL16105237 | 0.70 | MAPK14 (0.53) | LRRK2 | |
| SCHEMBL18745788 | 0.69 | CYP2A6 (0.68) | AXLCYP11B2KDM4EHSD17B10HTT | |
| SCHEMBL29818169 | 0.69 | CYP2A6 (0.68) | AXLCYP11B2KDM4EHSD17B10HTT | |
| SCHEMBL225149 | 0.69 | CYP2A6 (0.68) | AXLCYP11B2KDM4EHSD17B10HTT | |
| SCHEMBL6371302 | 0.68 | AXL (1.00) | AXLIDO1LRRK2MAP2K4PIM1 | |
| SCHEMBL19943059 | 0.67 | AXL (0.49) | AXLIDO1LRRK2CYP11B2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062885-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)PYRAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-12-09 | — | — | WO | disclosed |