Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 10/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | MMP13 | P45452 | 5/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | MMP12 | P39900 | 4/20 | 0.37 |
| ▸ | MMP14 | P50281 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 5/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491375 | 0.89 | ADAMTS5 (0.40) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8496482 | 0.88 | ADAMTS7 (0.42) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8495222 | 0.88 | ADAMTS7 (0.40) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8493121 | 0.88 | GRM2 (0.42) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8494417 | 0.86 | ADAMTS5 (0.39) | ADAMTS5MMP2MMP13ADAMTS4CTDSP1 | |
| SCHEMBL8497401 | 0.85 | NPSR1 (0.53) | ADAMTS5MMP2MMP13ADAMTS4SMN1; SMN2 | |
| SCHEMBL8496487 | 0.85 | ADAMTS5 (0.38) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8491697 | 0.85 | ADAMTS4 (0.53) | ADAMTS5MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL8491009 | 0.83 | ADAMTS5 (0.38) | ADAMTS5MMP2MMP13ADAMTS4MMP14 | |
| SCHEMBL8495680 | 0.83 | ADAMTS5 (0.42) | ADAMTS5MMP2MMP13ADAMTS4MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |