Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Barbituric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Barbituric Acid SCHEMBL141571 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL28237381 | 0.84 | ALDH1A1 (0.48) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL1470199 | 0.83 | HSD17B10 (0.50) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL9941322 | 0.83 | — | — | |
| Barbituric Acid SCHEMBL4560317 | 0.83 | ALDH1A1 (0.55) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL38707 | 0.83 | — | — | |
| Barbituric Acid SCHEMBL27648120 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL11674448 | 0.80 | ALDH1A1 (0.54) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Thiobarbituric SCHEMBL2455746 | 0.80 | ITGB3 (0.32) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 | |
| Barbituric Acid SCHEMBL1974368 | 0.80 | ALDH1A1 (0.52) | ALDH1A1CYP1A2HPGDHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373038-A | Flame resistant plastics containing guanidine barbiturates or guanidine thiobarbiturates, and also guanidine barbiturates and guanidine thiobarbiturate | CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) | 1994-12-13 | — | — | US | claimed |
| CN-110337435-A | Barbituric acid derivatives comprising cation group and lipophilic group | 特罗姆瑟大学-挪威北极圈大学 | 2019-10-15 | — | — | CN | disclosed |
| CN-101437886-B | Derivatives of pyrimidines as flame retardants | CIBA HOLDING INC | 2011-11-09 | — | — | CN | disclosed |
| CN-101437886-A | Derivatives of pyrimidines as flame retardants | CIBA HOLDING INC (CH) | 2009-05-20 | — | — | CN | disclosed |
| US-5981612-A | Production of flameproofed, rigid, isocyanate-based foams | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-09 | — | — | US | disclosed |
| US-5373038-A | Flame resistant plastics containing guanidine barbiturates or guanidine thiobarbiturates, and also guanidine barbiturates and guanidine thiobarbiturate | CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) | 1994-12-13 | — | — | US | disclosed |
| US-5373038-A | Flame resistant plastics containing guanidine barbiturates or guanidine thiobarbiturates, and also guanidine barbiturates and guanidine thiobarbiturate | CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) | 1994-12-13 | — | — | US | disclosed |
| EP-0567840-A1 | Guanidine barbiturate and guanidine thiobarbiturate as well as their use in plastics | DSM Chemie Linz GmbH (AT) | 1993-11-03 | — | — | EP | disclosed |
| EP-0567840-A1 | Guanidine barbiturate and guanidine thiobarbiturate as well as their use in plastics | DSM Chemie Linz GmbH (AT) | 1993-11-03 | — | — | EP | disclosed |