Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITPR3 | Q14573 | 8/20 | 0.57 |
| ▸ | ITPR1 | Q14643 | 4/20 | 0.57 |
| ▸ | ITPR2 | Q14571 | 3/20 | 0.57 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | INPP5A | Q14642 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500705 | 1.00 | ITPR3 (0.57) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3654572 | 0.97 | ITPR3 (0.59) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3075480 | 0.90 | GBA1 (0.66) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3073627 | 0.89 | PDPK1 (0.47) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL8500649 | 0.89 | PDPK1 (0.47) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3069188 | 0.89 | PDPK1 (0.47) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL8496685 | 0.89 | PDPK1 (0.47) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3645971 | 0.86 | ITPR3 (0.63) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3086336 | 0.84 | LPAR3 (0.52) | ITPR3ITPR1ITPR2INPPL1AKT1 | |
| SCHEMBL3080816 | 0.84 | LPAR3 (0.52) | ITPR3ITPR1ITPR2INPPL1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977078-A | CELL PERMEABLE ANTAGONIST | THE REGENTS OF THE UNIVESITY OF CALIFORNIA (US) | 1999-11-02 | — | — | US | disclosed |
| US-5880099-A | ALTERING CHLORIDE ION SECRETION ACROSS CELL MEMBRANE BY CONTACTING CELL WITH CELL PERMEABLE AGONIST OR ANTAGONIST OF INOSITOL POLYPHOSPHATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-03-09 | — | — | US | disclosed |