Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11495459 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| SCHEMBL2018449 | 0.83 | MEN1 (0.56) | ALDH1A1KDM4EHTTSMN1; SMN2BCHE | |
| SCHEMBL8497858 | 0.83 | KDM4E (0.67) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| SCHEMBL11439994 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| SCHEMBL7756966 | 0.81 | KDM4E (0.70) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL21879620 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4EHTTSMN1; SMN2BCHE | |
| SCHEMBL23367774 | 0.80 | ANPEP (0.58) | ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL13973066 | 0.80 | KDM4E (0.59) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL9079843 | 0.80 | KDM4E (0.68) | ALDH1A1KDM4EHTTSMN1; SMN2LTA4H | |
| SCHEMBL13086334 | 0.79 | LMNA (0.68) | KDM4ESMN1; SMN2LTA4HEPHX2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |