Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28663710 | 0.74 | GAA (0.36) | GAAHPGDMAPK1MAPTHSD17B1 | |
| SCHEMBL7298146 | 0.71 | — | — | |
| SCHEMBL30159080 | 0.66 | POLB (0.32) | MAPTPOLB | |
| SCHEMBL30159039 | 0.66 | POLB (0.32) | MAPTPOLB | |
| SCHEMBL8643529 | 0.66 | GAA (0.45) | GAAHPGDMAPK1MAPT | |
| SCHEMBL7590131 | 0.65 | GAA (0.44) | GAAHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL3799713 | 0.65 | GAA (0.44) | GAAHPGDMAPK1MAPT | |
| SCHEMBL20277765 | 0.64 | HSD17B1 (0.46) | HSD17B1MEN1ALDH1A1KMT2ACYP19A1 | |
| SCHEMBL20277764 | 0.64 | HSD17B1 (0.46) | HSD17B1MEN1ALDH1A1KMT2ACYP19A1 | |
| SCHEMBL11774345 | 0.62 | ALDH1A1 (0.39) | MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856349-A | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5563163-A | TREATMENT OF DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5512589-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP INC. (US) | 1996-04-30 | — | — | US | disclosed |