SCHEMBL8498656

SCHEMBL8498656

COc1ccc(CN(Cc2ccc(OC)cc2)/N=C/c2ccccc2)cc1.FC(F)(F)c1ccc(CN(Cc2ccccc2)/N=C/c2ccccc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
G6PC1 P35575 11/20 0.74
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
LTA4H P09960 1/20 0.41
BMP1 P13497 1/20 0.40
SLC2A1 P11166 1/20 0.40
GRIN1 Q05586 1/20 0.40
GRIN2B Q13224 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8498660 1.00 G6PC1 (0.74) G6PC1MEN1KMT2ALTA4HBMP1
SCHEMBL8497161 0.90 G6PC1 (0.73) G6PC1GRIN1GRIN2B
SCHEMBL8497166 0.90 G6PC1 (0.73) G6PC1GRIN1GRIN2B
SCHEMBL8498545 0.88 G6PC1 (0.88) G6PC1LTA4H
SCHEMBL8498548 0.88 G6PC1 (0.88) G6PC1LTA4H
SCHEMBL8495185 0.86 G6PC1 (1.00) G6PC1MEN1KMT2ALTA4H
SCHEMBL8495184 0.86 G6PC1 (1.00) G6PC1MEN1KMT2ALTA4H
SCHEMBL8498716 0.81 G6PC1 (0.76) G6PC1MEN1KMT2AGRIN1GRIN2B
SCHEMBL8498717 0.81 G6PC1 (0.76) G6PC1MEN1KMT2AGRIN1GRIN2B
SCHEMBL8495003 0.78 G6PC1 (0.78) G6PC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999040062-A1 HYDRAZONE DERIVATIVES NOVO NORDISK A/S (DK) 1999-08-12 WO claimed