Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 9/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGAV | P06756 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500073 | 0.87 | MAPT (0.49) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL8500043 | 0.79 | MAPT (0.57) | MAPTLMNASMN1; SMN2BCHEHDAC6 | |
| SCHEMBL8496894 | 0.77 | MAPT (0.55) | MAPTLMNASMN1; SMN2BCHEHDAC6 | |
| SCHEMBL7377637 | 0.77 | MAPT (0.55) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7864782 | 0.76 | MAPT (0.52) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL8498509 | 0.76 | MAPT (0.41) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7863172 | 0.76 | MAPT (0.51) | MAPTLMNASMN1; SMN2BCHEMAPK1 | |
| SCHEMBL7856497 | 0.75 | MAPT (0.50) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7856412 | 0.73 | TP53 (0.47) | LMNABCHEITGB3ITGAVMAPK1 | |
| SCHEMBL7377645 | 0.72 | BCHE (0.49) | MAPTLMNASMN1; SMN2BCHEHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |