⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8831896 | 0.86 | — | — | |
| SCHEMBL6838598 | 0.72 | PIK3C3 (0.31) | — | |
| SCHEMBL4740264 | 0.69 | TP53 (0.33) | — | |
| SCHEMBL6843578 | 0.66 | ALDH1A1 (0.38) | — | |
| SCHEMBL6845722 | 0.65 | ALDH1A1 (0.37) | — | |
| SCHEMBL17599181 | 0.64 | CDA (0.45) | — | |
| SCHEMBL11515949 | 0.63 | POLB (0.44) | — | |
| SCHEMBL4605352 | 0.63 | POLB (0.44) | — | |
| SCHEMBL4974460 | 0.62 | MAPK1 (0.33) | — | |
| SCHEMBL15014099 | 0.61 | TP53 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751934-B1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORP (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5688990-A | FORMING CHEMICAL INTERMEDIATES FOR AZETIDINONE COMPOUNDS THAT INHIBIT CHOLESTEROL BIOSYNTHESIS FOR PREVENTION OF ATHEROSCLEROSIS | SHANKAR BANDARPALLE B (US) | 1997-11-18 | — | — | US | disclosed |
| US-5627176-A | MIXED WITH CHOLESTEROL BIOSYNTHESIS INHIBITOR; PREVENTING ATHEROSCLEROSIS | SCHERING CORPORATION (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0751934-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995026334-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-10-05 | — | — | WO | disclosed |