Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | IL5 | P05113 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503153 | 1.00 | HIF1A (0.56) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL8500154 | 0.91 | CYP3A4 (0.60) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL8499983 | 0.89 | HIF1A (0.73) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL10539776 | 0.87 | NR3C1 (0.74) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL10538489 | 0.87 | NR3C1 (0.74) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL8500349 | 0.87 | NR3C1 (0.74) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL8501938 | 0.86 | CYP3A4 (0.57) | HIF1ACYP3A4SMN1; SMN2NR3C1ABCB11 | |
| SCHEMBL8500279 | 0.83 | NR3C1 (0.60) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL8499719 | 0.83 | NR3C1 (0.60) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL7204193 | 0.83 | NR3C1 (0.60) | HIF1ACYP3A4NR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5888995-A | ANTIINFLAMMATORY AND ANTIALLERGENIC AGENTS; A NOVEL GLUCOCORTICOSTEROID | ASTRA AKTIEBOLAG (SE) | 1999-03-30 | — | — | US | disclosed |
| US-5614514-A | Steroid esters | AKTIEBOLAGET ASTRA (SE) | 1997-03-25 | — | — | US | disclosed |