Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8451845 | 0.91 | BRS3 (0.49) | BRS3HRH3PLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL7831391 | 0.80 | BRS3 (0.41) | BRS3HRH3PLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL2961510 | 0.77 | CYP2A6 (0.46) | DAOLOXL2BCHEACHE | |
| SCHEMBL7571253 | 0.77 | HRH3 (0.47) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7843395 | 0.77 | HRH3 (0.47) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7505077 | 0.75 | LOXL2 (0.49) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7129739 | 0.75 | BRS3 (0.52) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL8498703 | 0.75 | BRS3 (0.49) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL10588302 | 0.75 | BRS3 (0.49) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7468902 | 0.75 | HRH3 (0.48) | BRS3HRH3TYMPGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891337-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036879-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |