Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499647 | 0.80 | BRS3 (0.42) | BRS3HRH3DAOPLA2G10PLA2G1B | |
| SCHEMBL8801601 | 0.77 | MAPT (0.50) | CYP2A6MAPTBCHEACHETRPV4 | |
| SCHEMBL8451845 | 0.75 | BRS3 (0.49) | BRS3HRH3DAOPLA2G10PLA2G1B | |
| SCHEMBL7505077 | 0.74 | LOXL2 (0.49) | BRS3HRH3DAOTYMPCYP2A6 | |
| SCHEMBL10588302 | 0.74 | BRS3 (0.49) | BRS3HRH3DAOTYMPCYP2A6 | |
| SCHEMBL8498703 | 0.74 | BRS3 (0.49) | BRS3HRH3DAOTYMPCYP2A6 | |
| SCHEMBL7468902 | 0.74 | HRH3 (0.48) | BRS3HRH3DAOTYMPCYP2A6 | |
| SCHEMBL7129739 | 0.74 | BRS3 (0.52) | BRS3HRH3DAOTYMPCYP2A6 | |
| SCHEMBL7468183 | 0.74 | BRS3 (0.47) | BRS3HRH3PLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL7843395 | 0.73 | HRH3 (0.47) | BRS3HRH3DAOTYMPSCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |