SCHEMBL849978

SCHEMBL849978

CS(=O)(=O)NC(=N)NCCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.50
CA2 P00918 4/20 0.47
ALDH1A1 P00352 3/20 0.47
CA12 O43570 3/20 0.47
CA9 Q16790 3/20 0.47
MAPT P10636 2/20 0.47
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.47
CYP3A4 P08684 1/20 0.47
GAA P10253 1/20 0.47
BLM P54132 1/20 0.47
GFER P55789 1/20 0.47
PMP22 Q01453 1/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HPGD P15428 1/20 0.46
EPHX1 P07099 1/20 0.46
CA1 P00915 3/20 0.45
PLAAT5 Q96KN8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17198897 0.84 ALDH1A1 (0.51) CA2ALDH1A1CA12CA9MAPT
SCHEMBL17199015 0.83 RAB9A (0.48) CA2ALDH1A1CA12CA9MAPT
Hydrochloric Acid SCHEMBL28480193 0.83 ALDH1A1 (0.50) CA2ALDH1A1CA12CA9MAPT
Hydrochloric Acid SCHEMBL28902086 0.82 RAB9A (0.47) CA2ALDH1A1CA12CA9MAPT
SCHEMBL850447 0.78 TAAR1 (0.55) CA2ALDH1A1CA12CA9MAPT
SCHEMBL13584139 0.77 NPC1 (0.59) CA2ALDH1A1CA12CA9LMNA
SCHEMBL3926232 0.75 NPC1 (0.57) POLBCA2CA12CA9LMNA
Hydrochloric Acid SCHEMBL13585003 0.75 NPC1 (0.57) CA2ALDH1A1CA12CA9MAPT
Phenformin SCHEMBL28415756 0.75 ALDH1A1 (0.57) CA2ALDH1A1CA12CA9MAPT
SCHEMBL14592922 0.75 NPC1 (0.52) CA2ALDH1A1CA12CA9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9109048-B2 Inhibition of tumor growth LYTIX BIOPHARMA AS (NO) 2015-08-18 US disclosed
US-8283315-B2 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2012-10-09 US disclosed
US-8143211-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2012-03-27 US disclosed
US-20080287346-A1 Bioactive peptides SVENDSEN JOHN SIGURD 2008-11-20 US disclosed
US-7439228-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2008-10-21 US disclosed
US-20080019993-A1 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2008-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287346-A1 Bioactive peptides VIP, NGLY1, IAPP POLB 2180/4885CA2 2343/4885ALDH1A1 4821/4885
US-20080019993-A1 Inhibition of tumour growth STING1, VIP, MIF POLB 789/4885CA2 994/4885ALDH1A1 4759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.