SCHEMBL8500249

SCHEMBL8500249

COc1cc2ccc(-c3ccsc3)nc2cc1OC

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 9/20 0.61
PDGFRA P16234 8/20 0.61
NPC1 O15118 2/20 0.50
ALDH1A1 P00352 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
KDM4E B2RXH2 1/20 0.47
RAB9A P51151 1/20 0.47
KCNH2 Q12809 2/20 0.42
HRH3 Q9Y5N1 2/20 0.42
GPBAR1 Q8TDU6 3/20 0.42
GAK O14976 1/20 0.41
GLA P06280 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
BACE1 P56817 1/20 0.41
SNCA P37840 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL479609 0.82 PDGFRB (0.70) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL6283958 0.81 PDGFRB (0.68) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
SCHEMBL8503434 0.78 PDGFRB (0.60) PDGFRBPDGFRAKDM4EGAK
SCHEMBL28596277 0.77 SMN1; SMN2 (0.66) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
SCHEMBL29501311 0.77 SMN1; SMN2 (0.66) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
SCHEMBL8501695 0.77 PDGFRB (0.59) PDGFRBPDGFRAALDH1A1SMN1; SMN2KDM4E
SCHEMBL8172666 0.76 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL31552887 0.76 KDM4E (0.63) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
SCHEMBL13870922 0.76 ALDH1A1 (0.50) PDGFRBPDGFRANPC1ALDH1A1SMN1; SMN2
SCHEMBL8526954 0.76 PDGFRB (0.61) PDGFRBPDGFRANPC1KCNH2GAK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE36256-E ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-07-20 US disclosed
US-5795889-A INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-08-18 US disclosed
US-5656643-A QUINOLIN PYRIDINE DERIVATIVES; USEFUL FOR TREATING CANCER, LEKEMIA, PSORIASIS, INFLAMMATORY DISODERS, BONE DISORDERS, ATHEROSCLEROSIS AND RESTENOSIS; CONTROLLS CELLULAR REPRODUCTION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-08-12 US disclosed
US-5480883-A Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-01-02 US disclosed
US-5409930-A Inhibits abnoramal cell proliferation; dimethoxyquinoline/ dimethylquinoline/ quinolineoxide/ and quinoxaline derivatives RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1995-04-25 US disclosed
EP-0584222-A4 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE POULENC RORER INT (US) 1994-07-06 EP disclosed
EP-0584222-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE. RHONE POULENC RORER INT (US) 1994-03-02 EP disclosed
WO-1992020642-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO disclosed