Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584634 | 0.83 | NPC1 (0.39) | ALDH1A1GAAKEAP1NFE2L2NPSR1 | |
| SCHEMBL8075300 | 0.81 | HSD11B1 (0.37) | HSD11B1TSHRALDH1A1GAAKEAP1 | |
| SCHEMBL7584650 | 0.80 | KMT2A (0.37) | ALDH1A1GAAKEAP1NFE2L2NPSR1 | |
| SCHEMBL7587276 | 0.80 | KMT2A (0.37) | ALDH1A1GAAKEAP1NFE2L2NPSR1 | |
| SCHEMBL5691171 | 0.78 | ALDH1A1 (0.35) | HSD11B1TSHRALDH1A1GAAMAPK1 | |
| SCHEMBL7876543 | 0.78 | KEAP1 (0.39) | TSHRALDH1A1GAAKEAP1NFE2L2 | |
| SCHEMBL7584054 | 0.78 | KMT2A (0.39) | ALDH1A1GAAKEAP1NFE2L2NPSR1 | |
| SCHEMBL6695757 | 0.77 | KEAP1 (0.34) | HSD11B1TSHRALDH1A1GAAKEAP1 | |
| SCHEMBL6392313 | 0.76 | KEAP1 (0.37) | TSHRALDH1A1GAAKEAP1NFE2L2 | |
| SCHEMBL8500779 | 0.75 | KEAP1 (0.39) | HSD11B1TSHRALDH1A1GAAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968970-A | TREATMENT OF HIV | G. D. SEARLE & COMPANY (US) | 1999-10-19 | — | — | US | disclosed |