Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | GRK2 | P25098 | 3/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856468 | 0.80 | TP53 (0.46) | TP53TSHRMEN1KMT2AFFAR1 | |
| SCHEMBL7864206 | 0.78 | TP53 (0.45) | TP53TSHRMEN1KMT2AFFAR1 | |
| SCHEMBL7856464 | 0.77 | TP53 (0.49) | TP53TSHRMEN1KMT2AROCK2 | |
| SCHEMBL7856412 | 0.75 | TP53 (0.47) | TP53TSHRMEN1KMT2AFFAR1 | |
| SCHEMBL7350700 | 0.72 | RAB9A (0.47) | TP53MEN1KMT2AMAPK1HSD17B10 | |
| SCHEMBL7864178 | 0.71 | TP53 (0.43) | TP53TSHRSIRT2LMNAMAPK1 | |
| SCHEMBL7863185 | 0.71 | AKR1C3 (0.56) | MEN1KMT2ALMNAALDH1A1GAA | |
| SCHEMBL7861566 | 0.70 | ROCK2 (0.41) | TP53TSHRROCK2GRK2PRKCA | |
| SCHEMBL7864712 | 0.69 | SIRT2 (0.45) | SIRT2LMNAMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL7864751 | 0.69 | SIRT2 (0.41) | TP53TSHRSIRT2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |