Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8888409 | 0.89 | FFAR1 (0.50) | FFAR1FFAR4PTGDR2PDGFRBPDGFRA | |
| SCHEMBL8499164 | 0.86 | PDGFRB (0.52) | FFAR1METPDGFRBPDGFRACDK8 | |
| SCHEMBL8504167 | 0.84 | CDK8 (0.47) | METPDGFRBPDGFRAEGLN1CDK8 | |
| SCHEMBL8499494 | 0.84 | THRB (0.51) | CDK8HCAR2 | |
| SCHEMBL8499648 | 0.81 | PDE3B (0.55) | FFAR1FFAR4PDGFRBPDGFRA | |
| SCHEMBL8889522 | 0.80 | PDGFRB (0.47) | FFAR1METFFAR4PDGFRBPDGFRA | |
| SCHEMBL8499166 | 0.80 | PSMB5 (0.54) | FFAR1FFAR4HPN | |
| SCHEMBL8499693 | 0.78 | PDGFRB (0.52) | PDGFRBPDGFRAEGLN1 | |
| Hydrochloric Acid SCHEMBL8501955 | 0.77 | PDGFRB (0.49) | METPDGFRBPDGFRA | |
| SCHEMBL8889438 | 0.77 | PDGFRB (0.55) | PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |